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ArrePath announces closing of their next financing round and appointment of new Board Chair

Princeton, NJ, June 23, 2025 – ArrePath, a company applying its proprietary artificial intelligence and machine learning platform together with deep R&D technical expertise to address the challenge of best-in-class antibacterial drug discovery, announced several business updates. First, the company has raised the next round of financing to advance its pipeline and continue to expand the scope and capabilities of its discovery platform. The Boehringer Ingelheim Venture Fund led the financing, which also included existing investors Insight Partners, Innospark, and Nor’easter Ventures, and new investor AB Magnitude. 

“We are grateful for the ongoing support of our strong investor base and welcome our new investor, AB Magnitude, to ArrePath,” said Kevin Krause, President and CEO. “This raise, in combination with our recently announced non-dilutive funding awards from PACE and CARB-X, enables ArrePath to advance our lead program, AP-001, towards development candidate nomination and eventual Phase 1 studies. In addition, the new funding will support expansion of our novel compounds active against non-tuberculous mycobacteria.” 

Following the closing of this financing, ArrePath concluded a search for a new Chair of the Board of Directors with the appointment of Diego Miralles, M.D. Dr. Miralles comes to ArrePath with extensive experience in the biotech and pharmaceutical industry in many strategic, development and leadership roles. He was recently nominated to the Board of Directors of Contineum (NASDAQ: CTNM) and serves on the Board of Artiva (NASDAQ: ARTV). Dr. Miralles, an Infectious Diseases trained clinician and scientist, has extensive executive experience including as CEO of AZURNA Therapeutics, Inc., Laronde, Inc., and Vividion Therapeutics, Inc, and President of Adaptive Therapeutics. Previous to these roles, Dr. Miralles held various senior executive and R&D leadership positions at Johnson & Johnson. 

Dr. Miralles received his M.D. degree from the University of Buenos Aires, completed his residency in Internal Medicine at the Mayo Clinic and a fellowship in Infectious Diseases at The New York Hospital/Cornell University and was on the faculty at Duke University. 

“We are excited to welcome Dr. Miralles to the ArrePath Board of Directors,” said Kevin Krause. “His decades of experience as an executive and board member in both private and public companies, along with his proven experience scaling emerging biotech companies, will provide invaluable insights and experience as we approach several near-term inflection points for ArrePath. I look forward to working with him as the company evolves into the next phase of growth.” 

“I am really excited to join Kevin Krause, our outstanding newly appointed CEO, and the Board at ArrePath,” said Diego Miralles. “The company’s AI discovery platform which, coupled with the team’s deep experience in antimicrobial development, will enable us to bring forward superior products to address unmet needs in antimicrobials. Recent approvals in antimicrobials demonstrate the continued need for improved products, a space where ArrePath will become a leader.” 

About ArrePath 

ArrePath combines the power of human intelligence with AI/ML to address the challenge of efficient drug discovery, which is a complex optimization process paired with an unimaginable number of chemical possibilities. Our AI/ML platform couples virtual and experimental compound design and testing to create efficiency at identifying novel compounds that are both active and have the attributes required to progress. To date, we have identified antibiotic hits active against three clinically novel targets. Of these, we are progressing AP-001 to focus on the large outpatient UTI market and a hospital avoidance strategy plus the potential for step-down from hospital-based IV therapies. We also have discovered multiple novel compound families active against non-tuberculous Mycobacteria (NTM). For more information on ArrePath’s innovative work and mission, please visit ArrePath.com

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Read the full press release here

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News Press Releases

Kevin Krause named President and CEO of ArrePath

Princeton, NJ, November 19, 2024 – ArrePath, Inc., an emerging biotechnology company focused on applying deep phenotypic insights and machine learning to the discovery of new anti-infectives, today announced the appointment of Kevin Krause as President and Chief Executive. Mr. Krause brings more than 25 years of experience in research, clinical development, commercialization, and corporate development in the biotech industry, as the company continues to expand its pipeline of internally discovered assets.

Mr. Krause most recently served as the Chief Strategy Officer of AN2 Therapeutics, Inc., a company applying boron chemistry to the discovery and development of novel therapies. In this role, he was the Project Team leader for AN2’s epetraborole Phase 2/3 NTM lung disease program, while overseeing various departments including Project Management, Clinical Operations, Regulatory, Quality, Medical Writing, and Corporate Development. Earlier in his career, he held various positions in R&D leadership and Corporate Business Development at Achaogen, Cerexa, and Theravance BioPharma, where he was instrumental in the clinical development and/or approval of Zemdri® (plazomicin), Avycaz® (ceftazidime-avibactam), Vibativ® (telavancin), Teflaro® (ceftaroline fosamil), Colobreathe® (inhaled colistin) and Quinsair® (inhaled levofloxacin).

Mr. Krause received an M.B.A. from the University of California, Berkeley Haas School of Business and a B.S. in Cell and Molecular Biology from San Francisco State University.

“We are thrilled to welcome Kevin as the new Chief Executive Officer of ArrePath”, said co-founder Dr. Zemer Gitai, on behalf of the company’s Board of Directors. “Thanks to his exceptional track record of visionary leadership, we are confident that Kevin will use the team’s momentum to advance their lead program to the clinic and unlock new opportunities for growth. This is an exciting new chapter for ArrePath and we look forward to the positive impact Kevin will bring to the company and its stakeholders.”

“I am honored to join ArrePath, which has made tremendous progress on the application of its proprietary AI/ML platform to discover antibacterials with novel mechanisms of action,” said Mr. Krause. “I look forward to working with the team to advance our lead program and to expand our existing portfolio.”

About ArrePath

ArrePath was founded with the mission to discover new and differentiated classes of anti-infectives to address antimicrobial resistance (AMR) through the application of state-of-the-art technologies and novel strategies. We apply world-class science and innovation in imaging and AI/ML technologies to identify and develop novel drugs to address global health issues. Our advanced machine learning (ML) drug discovery platform enables a rapid and efficient identification of new drug classes with desired activity profiles and clinical utility, coupled with a deep understanding of mechanism of action at the outset of the discovery process. 

For more information on ArrePath’s innovative work and mission, please visit www.arrepath.com.

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Reena Pagnoni
ArrePath
[email protected]
Phone: 609.423.1572

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News Press Releases

ArrePath Secures £1 Million Grant from PACE to Advance Novel Antibiotics Against Multidrug-Resistant Bacterial Infections

Princeton, NJ, November 19, 2024 – ArrePath, Inc., an emerging biotechnology company focused on applying deep phenotypic insights and machine learning to the discovery of new anti-infectives, today announced that it has been awarded a £1 million non-dilutive grant from PACE (Pathways to Antimicrobial Clinical Efficacy) in support of its efforts to develop a new class of antibiotics designed to address multidrug-resistant (MDR) infections, a growing global health threat.

Antimicrobial resistance renders standard antibiotic treatments ineffective, transforming some common infections into severe, life-threatening conditions. This resistance exacerbates the complexity and cost of medical care, jeopardizes immunocompromised patients, poses a significant public health crisis, and causes economic challenges worldwide.

To address the critical need for more effective treatment of microbial infections, ArrePath has leveraged its proprietary AI/ML platform to identify a unique class of small molecules with a mechanism of action distinct from current antibiotics. An antibiotic derived from these compounds would be active against a significant number of MDR infections, in particular those caused by E. coli, Klebsiella pneumoniae and related species.

Supported by this substantial funding from PACE, ArrePath will advance its lead program towards investigational new drug (IND)-enabling studies with a potential first clinical indication of complicated urinary tract infections (cUTIs) caused by MDR organisms. A dual delivery system—both intravenous and oral—will offer flexible treatment options across various healthcare settings.

“We are incredibly honored to have received this competitive award from PACE, which recognizes the potential of our innovative lead program powered by our proprietary AI/ML platform,” said Alita Miller, Ph.D., ArrePath Chief Scientific Officer. “This critical funding will enable ArrePath to continue developing a much-needed new class of antibiotics to combat multidrug-resistant Gram-negative infections. We are confident that our novel approach will be instrumental in addressing the escalating AMR crisis.”

Clive Mason, Programme Director, PACE, said: “We are delighted to welcome ArrePath into the PACE project portfolio. We congratulate them on their success after a highly competitive funding call seeking novel, early-stage antimicrobial therapeutics to tackle AMR. In addition to funding, we look forward to supporting them through access to a network of potential partners, advisors, mentors, and enabling technologies and capabilities.”

About PACE
PACE is a new and comprehensive approach to tackling one of the world’s most complex health challenges: antimicrobial resistance (AMR). PACE works with the AMR community and offers funding, support, and advice to help progress early-stage antimicrobial drug and diagnostic projects with greater speed and confidence – giving the best AMR innovations the greatest chance of success.

PACE selects, invests in and supports projects that address the world’s most threatening pathogens. In doing so, it will deliver innovations for onward development and investment, moving them closer to clinical trials. Working together with the brightest and best, PACE will help tackle this rising threat to global health.

PACE was founded in 2023 by LifeArcInnovate UK and Medicines Discovery Catapult, with a £30 million programme of funding and support to be deployed over five years.

About ArrePath

ArrePath was founded with the mission to discover new and differentiated classes of anti-infectives to address antimicrobial resistance (AMR) through the application of state-of-the-art technologies and novel strategies. We apply world-class science and innovation in imaging and AI/ML technologies to identify and develop novel drugs to address global health issues. Our advanced machine learning (ML) drug discovery platform enables a rapid and efficient identification of new drug classes with desired activity profiles and clinical utility, coupled with a deep understanding of mechanism of action at the outset of the discovery process. 

For more information on ArrePath’s innovative work and mission, please visit http://www.arrepath.com/.

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Reena Pagnoni
ArrePath
[email protected]
Phone: 609.423.1572

Categories
Events

BioNJ BioPartnering Conference, May 14, 2024 Liberty Science Center, NJ.

For more information, see: bionj.org/bionj-biopartnering-conference

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Events

European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), April 27-30, 2024, Barcelona, Spain.

ArrePath will be attending the 32nd European Congress of Clinical Microbiology & Infectious Diseases, which will take place in Lisbon, Portugal from April 23-26. Learn more.

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Events

MASSBIO 2024 Align Summit Cambridge, MA April 25, 2024

For more information, see: https://www.massbio.org/align

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Events

GRC: New Antibacterial and Development Conference, March 17-22 2024, Ventura CA

For more information, see: GRC: New Antibacterial and Development Conference

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Events

8th AMR Conference, March 6-7 2024, in Basel Switzerland

For more information, see: https://amr-conference.com/program-2024/

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Events

BIOTECH SHOWCASE: The Investor Conference For Innovators

For more information, see: Biotech Showcase

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Events

BioInfect 2023

ArrePath is looking forward to taking part in BioInfect 2023; Alderley Park Conference Centre, UK, 1st February 2023, where our CEO, Lloyd Payne, will be presenting in the ‘State of the AMR Nation’ panel discussion.

With the WHO declaring AMR one of the top 10 global public health threats facing humanity, a collaborative approach is needed across all sectors. BioInfect 2023 will look at the critical issues relating to the challenges of new anti-infective development, the endemic problem of resistance, and the considerations for creating a truly global and effective response to antimicrobial resistance.

For more information, see: Bionow | 2023 BioInfect Conference